Acute Lymphoblastic Leukemia
Acute Lymphoblastic Leukemia
The latest news, research, and perspectives in acute lymphoblastic leukemia (ALL). The most common type of leukemia in children, ALL develops when bone marrow produces a large number of immature lymphoblasts that grow quickly and replace normal cells in the bone marrow.
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Melissa BadamoAcute Lymphoblastic Leukemia | February 4, 2025
The approval is based on the E1910 trial, which compared blinatumomab and consolidation chemotherapy with chemotherapy alone.
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Andrew MorenoT-Cell Lymphoma | January 30, 2025
Therapy also in development for T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and mantle cell lymphoma.
Melissa BadamoAcute Lymphoblastic Leukemia | January 27, 2025
The US cancer mortality rate has declined by 34%, but the incidence of leukemia and other malignancies is increasing.
Andrew MorenoAcute Lymphoblastic Leukemia | January 22, 2025
A real-world study found blinatumomab plus ponatinib as more likely to be effective if used in earlier lines of therapy.
Andrew MorenoAcute Lymphoblastic Leukemia | January 10, 2025
Issues addressed include mandatory versus optional biopsy, informed consent, and safety in both adult and pediatric patients.
Andrew MorenoTransplantation & Cellular Therapy | January 6, 2025
A compound to assist CAR T-cell therapy by targeting and suppressing YTHDF2 is in development.
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Patrick DalyAcute Lymphoblastic Leukemia | December 23, 2024
Continued treatment and follow-up of patients after the interim analysis demonstrate the durability of response to revumenib.
Andrew MorenoMeeting News | December 9, 2024
The approach demonstrated safety and produced response in B-ALL, DLBCL, follicular lymphoma, and MCL.
Melissa BadamoAcute Lymphoblastic Leukemia | November 21, 2024
The approval is based on results of the FELIX trial, which evaluated the safety and efficacy of obe-cel.
Melissa BadamoAcute Myeloid Leukemia | November 19, 2024
The approval is based on results of the phase I/II AUGMENT-101 trial, where revumenib achieved a CR+CRh rate of 21%.
Leah LawrencePrint | November 18, 2024
The interest in using quantitative tests to measure residual cancer cells continues to expand in the arena of blood cancers.
Andrew MorenoAcute Lymphoblastic Leukemia | November 13, 2024
The one-year overall survival rate of 90%, and the MRD negativity rate was 94%.
Rebecca AraujoAcute Lymphoblastic Leukemia | September 23, 2024
The phase Ib/II FELIX trial found that obe-cel is effective for the treatment of relapsed or refractory adult B-cell ALL.
Elias Jabbour, MDAcute Lymphoblastic Leukemia | September 10, 2024
In the FELIX trial, obe-cel, a CAR-T therapy, achieved a 78% response rate and a 97% MRD negativity rate.
Melissa BadamoAcute Lymphoblastic Leukemia | September 5, 2024
Researchers identified several risk factors that predicted thrombosis in adults with ALL.
Melissa BadamoAcute Lymphoblastic Leukemia | September 5, 2024
A study described how the implementation of tisa-cel has affected treatment outcomes in B-ALL.
Melissa BadamoAcute Lymphoblastic Leukemia | September 5, 2024
MRD-negative CR status was able to predict long-term survival in newly diagnosed PH+ ALL.
Patrick DalyAcute Lymphoblastic Leukemia | September 16, 2024
Of the 127 patients who received obe-cel infusion, 74% achieved CR/CRi and 95% had MRD negativity.
Patrick DalyAcute Lymphoblastic Leukemia | July 2, 2024
The US FDA approved blinatumomab for the treatment of CD19-positive, Philadelphia chromosome-negative B-cell precursor ALL.
Andrew MorenoAcute Lymphoblastic Leukemia | June 6, 2024
Investigators identified pre- and postinfusion factors linked to severe hematotoxicity, as defined by EHA/EBMT criteria.
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