Non-Hispanic Black women had the highest odds for hypertensive disorders of pregnancy, preterm birth, and fetal death. Phase 1b data suggest that continuous low-dose lenalidomide improves the therapeutic index in patients RRMM. ISB 2001, a novel BCMA-targeting trispecific antibody, showed increased expression of T-cell activation cell surface markers. A QSP model of ISB 2001, a novel trispecific antibody, offers an effective pathway for designing phase 1 studies. Efficacy and safety profile data were presented at the AACR Annual Meeting 2025. CR1-02 was well-tolerated and led to stable disease in patients with relapsed or refractory AML.