Constantine Tam, MD, MBBS

About Professor Tam

Professor Tam is a globally recognized leader in hematologic oncology, serving as Head of the Lymphoma Service at Alfred Health and Professor of Hematology at Monash University in Melbourne, Australia. He earned his MD and medical degree with honors from the University of Melbourne, completed dual training in hematology and hematopathology, and went on to complete a prestigious leukemia fellowship at University of Texas MD Anderson Cancer Center.

Known for his innovative work in blood cancer treatments, Professor Tam has played a key role in developing targeted therapies. He is the global lead investigator for the BTK inhibitor zanubrutinib, overseeing its development from the first patient dosed in Melbourne through international regulatory approvals. His groundbreaking study combining ibrutinib and venetoclax for chronic lymphocytic leukemia (CLL) was the first of its kind, with results published in the New England Journal of Medicine just five years after the trial began.

Before joining Alfred Health, Professor Tam led the Low-Grade Lymphoma and CLL program at the Peter MacCallum Cancer Center and Royal Melbourne Hospital for over a decade. In 2015, he led Australia’s participation in the pivotal trial for chimeric antigen receptor T-cell therapy in diffuse large B-cell lymphoma, helping secure public access to this life-saving treatment.

With over 240 peer-reviewed publications and more than 17,000 citations, Professor Tam’s research has significantly influenced modern lymphoma and CLL treatment.

Articles by Constantine Tam, MD, MBBS

Constantine Tam, MD, MBBSChronic Lymphocytic Leukemia | June 3, 2025
Dr. Tam reviews 5-year data from SEQUOIA showing strong efficacy of zanubrutinib in older CLL patients with 17p deletion.
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