What Are the Latest Strategies for Managing Paroxysmal Nocturnal Hemoglobinuria?

In this episode of “Blood Cancer Talks,” the hosts discuss paroxysmal nocturnal hemoglobinuria (PNH) with 2023 American Society of Hematology President Robert Brodsky, MD, of the Johns Hopkins School of Medicine.

They delve into the treatment and management of PHN and highlight a paper on the subject that Dr. Brodksy published in Blood. Dr. Brodsky and the hosts also discuss research evaluating pegcetacoplan versus eculizumab in PNH, as well as a phase II study of danicopan in patients with PNH who did not have an adequate response to eculizumab.

Additionally, Dr. Brodsky and the hosts review research on complement and the prothrombotic state and explore the data on alternative donor bone marrow transplant with post-transplant cyclophosphamide a frontline therapy for acquired severe aplastic anemia.

This podcast originally appeared on Blood Cancer Talks.